Assay Detail
Binding
CHEMBL1785906
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Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.25 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574782 | — | — | 1 | 8.12 |
| CHEMBL1085033 | — | — | 1 | 8.03 |
| CHEMBL1085034 | — | — | 1 | 8.01 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.25 |
| CHEMBL73460 | — | — | 1 | 7.09 |
| CHEMBL1083382 | — | — | 1 | 7.00 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.60 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL1084951 | — | — | 1 | 6.47 |
| CHEMBL1082898 | — | — | 1 | 6.39 |
| CHEMBL1083684 | — | — | 1 | 6.13 |
| CHEMBL1084063 | — | — | 1 | 5.81 |
| CHEMBL1085095 | — | — | 1 | 5.77 |
| CHEMBL1084064 | — | — | 1 | 5.73 |
| CHEMBL1085094 | — | — | 1 | 5.68 |
| CHEMBL1085467 | — | — | 1 | 5.64 |
| CHEMBL1085092 | — | — | 1 | 5.61 |
| CHEMBL1083381 | — | — | 1 | 5.60 |
| CHEMBL1085093 | — | — | 1 | 5.52 |
| CHEMBL1084856 | — | — | 1 | 5.45 |
| CHEMBL1083383 | — | — | 1 | 5.42 |
| CHEMBL1083756 | — | — | 1 | 5.38 |
| CHEMBL1084702 | — | — | 1 | 5.37 |
| CHEMBL23285 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574782 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL1085033 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL1085034 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL73460 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL1083382 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1084951 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL1082898 | — | Ki | = | 407.0 | nM | 6.39 |
| CHEMBL1083684 | — | Ki | = | 737.0 | nM | 6.13 |
| CHEMBL1084063 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL1085095 | — | Ki | = | 1710.0 | nM | 5.77 |
| CHEMBL1084064 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL1085094 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL1085467 | — | Ki | = | 2280.0 | nM | 5.64 |
| CHEMBL1085092 | — | Ki | = | 2440.0 | nM | 5.61 |
| CHEMBL1083381 | — | Ki | = | 2495.0 | nM | 5.60 |
| CHEMBL1085093 | — | Ki | = | 3050.0 | nM | 5.52 |
| CHEMBL1084856 | — | Ki | = | 3590.0 | nM | 5.45 |
| CHEMBL1083383 | — | Ki | = | 3830.0 | nM | 5.42 |
| CHEMBL1083756 | — | Ki | = | 4160.0 | nM | 5.38 |
| CHEMBL1084702 | — | Ki | = | 4260.0 | nM | 5.37 |
| CHEMBL23285 | — | Ki | = | 5900.0 | nM | 5.23 |