Assay Detail
Binding
CHEMBL1785908
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Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.05 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 9.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.60 |
| CHEMBL1085034 | — | — | 1 | 8.30 |
| CHEMBL1084951 | — | — | 1 | 8.24 |
| CHEMBL1083383 | — | — | 1 | 8.19 |
| CHEMBL1084856 | — | — | 1 | 7.31 |
| CHEMBL1082898 | — | — | 1 | 7.29 |
| CHEMBL1083382 | — | — | 1 | 7.28 |
| CHEMBL574782 | — | — | 1 | 7.28 |
| CHEMBL1083381 | — | — | 1 | 7.27 |
| CHEMBL1085033 | — | — | 1 | 7.27 |
| CHEMBL1084063 | — | — | 1 | 7.22 |
| CHEMBL1085094 | — | — | 1 | 7.21 |
| CHEMBL1085467 | — | — | 1 | 7.19 |
| CHEMBL1083684 | — | — | 1 | 7.19 |
| CHEMBL73460 | — | — | 1 | 7.15 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.93 |
| CHEMBL1085093 | — | — | 1 | 6.25 |
| CHEMBL1084064 | — | — | 1 | 6.24 |
| CHEMBL1085095 | — | — | 1 | 6.22 |
| CHEMBL1083756 | — | — | 1 | 6.07 |
| CHEMBL1084702 | — | — | 1 | 5.29 |
| CHEMBL23285 | — | — | 1 | 5.14 |
| CHEMBL1085092 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1085034 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1084951 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL1083383 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL1084856 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL1082898 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL1083382 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL574782 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL1083381 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1085033 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1084063 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL1085094 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL1085467 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1083684 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL73460 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL1085093 | — | Ki | = | 556.0 | nM | 6.25 |
| CHEMBL1084064 | — | Ki | = | 581.0 | nM | 6.24 |
| CHEMBL1085095 | — | Ki | = | 605.0 | nM | 6.22 |
| CHEMBL1083756 | — | Ki | = | 861.0 | nM | 6.07 |
| CHEMBL1084702 | — | Ki | = | 5150.0 | nM | 5.29 |
| CHEMBL23285 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL1085092 | — | Ki | = | 8370.0 | nM | 5.08 |