Assay Detail
Binding
CHEMBL1786237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.30 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782530 | — | — | 1 | 9.00 |
| CHEMBL1782531 | — | — | 1 | 7.72 |
| CHEMBL1782521 | — | — | 1 | 7.70 |
| CHEMBL1782524 | — | — | 1 | 7.40 |
| CHEMBL1782522 | — | — | 1 | 7.29 |
| CHEMBL1782516 | — | — | 1 | 7.28 |
| CHEMBL1782526 | — | — | 1 | 7.26 |
| CHEMBL1782518 | — | — | 1 | 7.22 |
| CHEMBL1782520 | — | — | 1 | 7.15 |
| CHEMBL1782513 | — | — | 1 | 6.92 |
| CHEMBL1782525 | — | — | 1 | 6.82 |
| CHEMBL1782514 | — | — | 1 | 6.70 |
| CHEMBL1782515 | — | — | 1 | 6.68 |
| CHEMBL1782527 | — | — | 1 | 6.66 |
| CHEMBL1782509 | — | — | 1 | 6.42 |
| CHEMBL1782517 | — | — | 1 | 6.35 |
| CHEMBL1782512 | — | — | 1 | 6.34 |
| CHEMBL1782528 | — | — | 1 | 6.01 |
| CHEMBL1782511 | — | — | 1 | 5.72 |
| CHEMBL1782532 | — | — | 1 | 5.64 |
| CHEMBL1782533 | — | — | 1 | 5.62 |
| CHEMBL1782529 | — | — | 1 | 5.57 |
| CHEMBL1782523 | — | — | 1 | 5.35 |
| CHEMBL1782519 | — | — | 1 | 5.31 |
| CHEMBL1782505 | — | — | 1 | 5.28 |
| CHEMBL1782508 | — | — | 1 | 5.27 |
| CHEMBL1738915 | — | — | 1 | 5.24 |
| CHEMBL1782510 | — | — | 1 | 5.22 |
| CHEMBL1782506 | — | — | 1 | 5.21 |
| CHEMBL1782507 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782530 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1782531 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1782521 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1782524 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1782522 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1782516 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1782526 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1782518 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1782520 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1782513 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1782525 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1782514 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1782515 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1782527 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1782509 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1782517 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1782512 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1782528 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL1782511 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1782532 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1782533 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1782529 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1782523 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1782519 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1782505 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1782508 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1738915 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1782510 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1782506 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1782507 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1204914 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL1738916 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL84095 | — | IC50 | = | 119000.0 | nM | - |