Compound Detail
CHEMBL1782508
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Basic Information
| ChEMBL ID | CHEMBL1782508 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YVLOAUNTFMOROX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
242.2
MW (Da)
2.53
ALogP
4
HBA
1
HBD
68.3
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | IC50 | 5.54 | 5.54 | 2900.0 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 5.27 | 5.27 | 5400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-2 | IC50 | = | 2900.0 | nM | 5.54 | Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 min... | 21507633 |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 5400.0 | nM | 5.27 | Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 min... | 21507633 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21507633 | 10.1016/j.bmcl.2011.03.030 | Serine/threonine-protein kinase pim-1 | 1 |
| 21507633 | 10.1016/j.bmcl.2011.03.030 | Serine/threonine-protein kinase pim-2 | 1 |
Data from ChEMBL 36 via Core Engine