Assay Detail
Binding
CHEMBL1786288
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Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-EBNA |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Fluorescent Ligands for the Human 5-HT1A Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.00 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1784931 | — | — | 1 | 8.70 |
| CHEMBL33150 | — | — | 1 | 8.62 |
| CHEMBL1784939 | — | — | 1 | 8.62 |
| CHEMBL1784933 | — | — | 1 | 8.30 |
| CHEMBL42810 | — | — | 1 | 8.26 |
| CHEMBL1784934 | — | — | 1 | 8.15 |
| CHEMBL1784935 | — | — | 1 | 8.05 |
| CHEMBL1784930 | — | — | 1 | 7.96 |
| CHEMBL1784932 | — | — | 1 | 7.82 |
| CHEMBL1784938 | — | — | 1 | 7.01 |
| CHEMBL1784937 | — | — | 1 | 6.46 |
| CHEMBL1784936 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1784931 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL33150 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1784939 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1784933 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL42810 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL1784934 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1784935 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1784930 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1784932 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1784938 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL1784937 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL1784936 | — | Ki | > | 1000.0 | nM | - |