Assay Detail
Binding
CHEMBL1786326
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Inhibition of human recombinant iNOS by microtiter plate assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.77 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783094 | — | — | 1 | 7.52 |
| CHEMBL1783097 | — | — | 1 | 6.92 |
| CHEMBL1783093 | — | — | 1 | 6.75 |
| CHEMBL1783095 | — | — | 1 | 6.70 |
| CHEMBL1783072 | CYCLOBUTANECARBOXIMIDAMIDE | — | 1 | 6.42 |
| CHEMBL1783092 | — | — | 1 | 6.16 |
| CHEMBL1783071 | CYCLOPROPANECARBOXIMIDAMIDE | — | 1 | 6.10 |
| CHEMBL114551 | GW-274150 | 2.0 | 1 | 5.85 |
| CHEMBL1229853 | CYCLOPENTANECARBOXIMIDAMIDE | — | 1 | 5.36 |
| CHEMBL1783091 | — | — | 1 | 5.28 |
| CHEMBL1783090 | — | — | 1 | 5.05 |
| CHEMBL1783098 | — | — | 1 | 5.03 |
| CHEMBL1783096 | — | — | 1 | 4.85 |
| CHEMBL1783074 | — | — | 1 | 4.29 |
| CHEMBL1783089 | — | — | 1 | 4.24 |
| CHEMBL1783073 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783094 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1783097 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1783093 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1783095 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1783072 | CYCLOBUTANECARBOXIMIDAMIDE | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1783092 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1783071 | CYCLOPROPANECARBOXIMIDAMIDE | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL114551 | GW-274150 | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1229853 | CYCLOPENTANECARBOXIMIDAMIDE | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1783091 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1783090 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1783098 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1783096 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1783074 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL1783089 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL1783073 | — | IC50 | > | 100000.0 | nM | - |