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Assay Detail

CHEMBL1786467

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Functional
Antiplatelet activity in human platelet rich plasma assessed as inhibition of platelet aggregation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Plasma
Cell Type Platelet
Confidence 1 — Organism
Curated By Autocuration

Publication

Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
Ishikawa M, Hashimoto Y.
J Med Chem (2011) 54 : 1539 -1554
PubMed 21344906 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.75 7.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL599119 1 7.43
CHEMBL599138 1 7.08
CHEMBL1782661 1 7.05
CHEMBL1782663 1 7.00
CHEMBL1083695 1 6.89
CHEMBL1782657 1 6.77
CHEMBL1782660 1 6.64
CHEMBL1782662 1 6.54
CHEMBL598737 1 6.54
CHEMBL1782659 1 6.29
CHEMBL1782658 1 6.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL599119 IC50 = 37.0 nM 7.43
CHEMBL599138 IC50 = 83.0 nM 7.08
CHEMBL1782661 IC50 = 90.0 nM 7.05
CHEMBL1782663 IC50 = 99.0 nM 7.00
CHEMBL1083695 IC50 = 130.0 nM 6.89
CHEMBL1782657 IC50 = 170.0 nM 6.77
CHEMBL1782660 IC50 = 230.0 nM 6.64
CHEMBL1782662 IC50 = 290.0 nM 6.54
CHEMBL598737 IC50 = 290.0 nM 6.54
CHEMBL1782659 IC50 = 510.0 nM 6.29
CHEMBL1782658 IC50 = 930.0 nM 6.03