Assay Detail
Binding
CHEMBL1786486
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Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Endoplasmic reticulum chaperone BiP (CHEMBL1781865) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 5.94 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462871 | — | — | 1 | 7.22 |
| CHEMBL470334 | — | — | 1 | 7.10 |
| CHEMBL515570 | — | — | 1 | 6.64 |
| CHEMBL473972 | — | — | 1 | 6.60 |
| CHEMBL538168 | — | — | 1 | 6.11 |
| CHEMBL1784882 | — | — | 1 | 6.00 |
| CHEMBL516357 | — | — | 1 | 6.00 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | 5.66 |
| CHEMBL1614768 | — | — | 1 | 5.62 |
| CHEMBL1784884 | — | — | 1 | 5.57 |
| CHEMBL1784883 | — | — | 1 | 5.36 |
| CHEMBL516197 | — | — | 1 | 5.17 |
| CHEMBL451058 | — | — | 1 | 5.13 |
| CHEMBL1614761 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462871 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL470334 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL515570 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL473972 | — | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL538168 | — | Kd | = | 770.0 | nM | 6.11 |
| CHEMBL1784882 | — | Kd | = | 990.0 | nM | 6.00 |
| CHEMBL516357 | — | Kd | = | 990.0 | nM | 6.00 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | Kd | = | 2170.0 | nM | 5.66 |
| CHEMBL1614768 | — | Kd | = | 2410.0 | nM | 5.62 |
| CHEMBL1784884 | — | Kd | = | 2710.0 | nM | 5.57 |
| CHEMBL1784883 | — | Kd | = | 4360.0 | nM | 5.36 |
| CHEMBL516197 | — | Kd | = | 6800.0 | nM | 5.17 |
| CHEMBL451058 | — | Kd | = | 7460.0 | nM | 5.13 |
| CHEMBL1614761 | — | Kd | = | 12360.0 | nM | 4.91 |