Assay Detail
Binding
CHEMBL1786489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Grp78 by isothermal titration calorimetric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Endoplasmic reticulum chaperone BiP (CHEMBL1781865) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.08 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462871 | — | — | 1 | 7.00 |
| CHEMBL470334 | — | — | 1 | 6.70 |
| CHEMBL515570 | — | — | 1 | 6.46 |
| CHEMBL516357 | — | — | 1 | 6.06 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | 5.42 |
| CHEMBL516197 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462871 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL470334 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL515570 | — | Kd | = | 350.0 | nM | 6.46 |
| CHEMBL516357 | — | Kd | = | 870.0 | nM | 6.06 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | Kd | = | 3830.0 | nM | 5.42 |
| CHEMBL516197 | — | Kd | = | 14140.0 | nM | 4.85 |