Assay Detail
Functional
CHEMBL1786812
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Agonist activity at human P2Y4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.36 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | 3.0 | 1 | 7.05 |
| CHEMBL1767408 | DIQUAFOSOL TETRASODIUM | 4.0 | 1 | 6.06 |
| CHEMBL1784888 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1767408 | DIQUAFOSOL TETRASODIUM | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1784888 | — | EC50 | = | 1100.0 | nM | 5.96 |