Assay Detail
Binding
CHEMBL1787220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of muscarinic receptor in rat brain synaptosomes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609132 | — | — | 1 | 7.00 |
| CHEMBL1782708 | LUPINYLPHENOTHIAZINE | — | 1 | 7.00 |
| CHEMBL1782718 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609132 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1782708 | LUPINYLPHENOTHIAZINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1782718 | — | IC50 | = | 100.0 | nM | 7.00 |