Muscarinic acetylcholine receptor · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P08482. Use UniProt P08482 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08482 as the stable identity anchor, then attach disease evidence before program review.
Muscarinic acetylcholine receptor M1
Review this target as Muscarinic acetylcholine receptor, mapped to UniProt P08482. ChEMBL maps the protein component as Muscarinic acetylcholine receptor M1. Sequence length is 460 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor as ChEMBL target CHEMBL1907609, mapped to UniProt P08482. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Muscarinic acetylcholine receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P08482 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M1 |
| UniProt Accession | P08482 |
| Component Type | Protein |
| Sequence Length | 460 aa |
Muscarinic acetylcholine receptor M1
Review this target as Muscarinic acetylcholine receptor, mapped to UniProt P08482. ChEMBL maps the protein component as Muscarinic acetylcholine receptor M1. Sequence length is 460 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL351561 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL320611 | 10.53 | Ki | 0.0297 | Preclinical |
| CHEMBL156050 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL142136 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL143228 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL569713 | 10.1 | Ki | 0.08 | Approved |
| CHEMBL350223 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL160582 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL141269 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL321214 | 9.78 | Ki | 0.166 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 235 | 474 | 6.5 |
| assay format | 113 | 391 | 6.4 |
| protein format | 113 | 130 | 6.9 |
| cell membrane format | 42 | 159 | 6.1 |
| cell-based format | 1 | 1 | 8.2 |
| subcellular format | 1 | 3 | 7.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 4 | 6.3 |
| tissue-based format | 4 | 0 | — |
| cell membrane format | 2 | 0 | — |
| organism-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |