Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL321214

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CN1CC2CC1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2

Basic Information

ChEMBL ID CHEMBL321214
Phase Preclinical
Structure Type MOL
InChI Key XXWOCVWJOICKHA-RRWXTXHCSA-N
5
Targets
10
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

351.4
MW (Da)
2.95
ALogP
4
HBA
1
HBD
49.8
PSA (Ų)
0.86
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25NO3
MW 351.45
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness 0.17

Activity Summary

Ki 6 meas. best 9.78
Kd 4 meas. best 9.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 9.78 9.6533 0.2 3
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 9.75 9.75 0.2 1
Muscarinic acetylcholine receptor
CHEMBL2094109
Kd 9.52 9.435 0.3 2
Muscarinic acetylcholine receptor
CHEMBL2094109
Ki 9.32 9.32 0.5 1
Glutathione S-transferase theta-1
CHEMBL2423
Ki 9.17 9.17 0.7 1
Cavia porcellus
CHEMBL369
Kd 8.73 8.72 1.9 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1956033 10.1021/jm00115a003 Muscarinic acetylcholine receptor 6
1956033 10.1021/jm00115a003 Cavia porcellus 2
1956033 10.1021/jm00115a003 Muscarinic acetylcholine receptor M2 1
1956033 10.1021/jm00115a003 Glutathione S-transferase theta-1 1

Data from ChEMBL 36 via Core Engine