Assay Detail
Functional
CHEMBL841895
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Inhibition against methacholine induced phasic contraction in guinea pig ileum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.89 | 10.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320611 | — | — | 1 | 10.13 |
| CHEMBL110808 | — | — | 1 | 8.81 |
| CHEMBL326640 | — | — | 1 | 8.76 |
| CHEMBL110339 | — | — | 1 | 8.73 |
| CHEMBL321214 | — | — | 1 | 8.71 |
| CHEMBL322582 | — | — | 1 | 8.21 |
| CHEMBL318812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320611 | — | Kd | = | 0.07413 | nM | 10.13 |
| CHEMBL110808 | — | Kd | = | 1.549 | nM | 8.81 |
| CHEMBL326640 | — | Kd | = | 1.738 | nM | 8.76 |
| CHEMBL110339 | — | Kd | = | 1.862 | nM | 8.73 |
| CHEMBL321214 | — | Kd | = | 1.95 | nM | 8.71 |
| CHEMBL322582 | — | Kd | = | 6.166 | nM | 8.21 |
| CHEMBL318812 | — | Kd | = | 0.006457 | nM | - |