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Target Snapshot

CHEMBL2094109 Target Snapshot

Muscarinic acetylcholine receptor · PROTEIN FAMILY · Homo sapiens

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593Compounds
129Assays
11Approved Drugs
711.0Activities
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Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Muscarinic acetylcholine receptor shows approved-linked disease relevance led by chronic obstructive pulmonary disease. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P20309. Start with chronic obstructive pulmonary disease, then reuse UniProt P20309 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with chronic obstructive pulmonary disease, then reuse UniProt P20309 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 2 linked drugs
Open source guide
Disease program
chronic obstructive pulmonary disease

Muscarinic acetylcholine receptor shows approved-linked disease relevance led by chronic obstructive pulmonary disease. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with chronic obstructive pulmonary disease because it currently carries approved-linked support. Linked drugs include DAROTROPIUM BROMIDE, GLYCOPYRRONIUM TOSYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Muscarinic acetylcholine receptor as ChEMBL target CHEMBL2094109, mapped to UniProt P20309. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Muscarinic acetylcholine receptor
PROTEIN FAMILY · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2094109
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P20309
Muscarinic acetylcholine receptor M3
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Muscarinic acetylcholine receptor is the right protein anchor across sources, using UniProt P20309 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why chronic obstructive pulmonary disease is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameMuscarinic acetylcholine receptor
Target TypePROTEIN FAMILY
OrganismHomo sapiens
UniProtP20309
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMuscarinic acetylcholine receptor M3
UniProt AccessionP20309
Component TypeProtein
Sequence Length590 aa

Muscarinic acetylcholine receptor M3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Muscarinic acetylcholine receptor, mapped to UniProt P20309. ChEMBL maps the protein component as Muscarinic acetylcholine receptor M3. Sequence length is 590 aa.

Mapped IDP20309
Review nameMuscarinic acetylcholine receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Muscarinic acetylcholine receptor shows approved-linked disease relevance led by chronic obstructive pulmonary disease. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
chronic obstructive pulmonary disease
2 linked drugs · 2 direct · 2 efficacy
Linked drugDAROTROPIUM BROMIDE
Linked drugGLYCOPYRRONIUM TOSYLATE
Approved-linked Approved
Hyperhidrosis
2 linked drugs · 2 direct · 2 efficacy
Linked drugGLYCOPYRRONIUM TOSYLATE
Linked drugSOFPIRONIUM BROMIDE
Approved-linked Approved
cardiac arrhythmia
1 linked drug · 1 direct · 1 efficacy
Linked drugGLYCOPYRRONIUM TOSYLATE
Approved-linked Approved
cerebral palsy
1 linked drug · 1 direct · 1 efficacy
Linked drugGLYCOPYRRONIUM TOSYLATE
Approved-linked Approved
peptic ulcer disease
1 linked drug · 1 direct · 1 efficacy
Linked drugGLYCOPYRRONIUM TOSYLATE
Clinical signal Phase II
overactive bladder
1 linked drug · 1 direct · 1 efficacy
Linked drugAFACIFENACIN
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with chronic obstructive pulmonary disease because it currently carries approved-linked support. Linked drugs include DAROTROPIUM BROMIDE, GLYCOPYRRONIUM TOSYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasechronic obstructive pulmonary disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

11
Approved
3
Phase II
Assay Mix

Activity Type Distribution

IC50118.0
KI386.0
EC5058.0
KD149.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL318812 10.92 Kd 0.01202 Preclinical
CHEMBL320611 10.46 Kd 0.03467 Preclinical
CHEMBL12980 10.35 Ki 0.045 Preclinical
CHEMBL320611 10.27 Ki 0.054 Preclinical
CHEMBL287868 9.57 Ki 0.27 Preclinical
CHEMBL331497 9.57 Ki 0.27 Preclinical
CHEMBL321214 9.52 Kd 0.302 Preclinical
CHEMBL517712 9.49 Ki 0.32 Approved
CHEMBL318812 9.35 Ki 0.449 Preclinical
CHEMBL321214 9.32 Ki 0.475 Preclinical
Distribution

pChEMBL Value Distribution

71
5.0
93
5.5
98
6.0
74
6.5
55
7.0
36
7.5
30
8.0
16
8.5
15
9.0
7
9.5
pChEMBL
Approved Drugs

Approved Drugs

OLANZAPINE
CHEMBL715
Approved 1996
Properties Compare Identifier
CLOZAPINE
CHEMBL42
Approved 1989
Properties Compare Identifier
CARBAMOYLCHOLINE
CHEMBL965
Approved 1972
Properties Compare Identifier
CARBACHOL
CHEMBL14
Approved 1972
Properties Compare Identifier
ATROPINE
CHEMBL517712
Approved 1960
Properties Compare Identifier
BETHANECHOL
CHEMBL1482
Approved 1948
Properties Compare Identifier
Assay Landscape

Assay Landscape

129
Total Assays
279
Tested Compounds
3
Assay Types
Binding — 82 assays, 279 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 65 147 6.5
tissue-based format 13 123 6.8
cell-based format 3 6 5.5
assay format 1 3 8.7
Functional — 46 assays, 106 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 24 56 6.3
assay format 16 29 6.5
organism-based format 4 0 —
cell-based format 2 21 5.1
ADME — 1 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 10 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine