Assay Detail
Functional
CHEMBL684531
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of methacholine induced phasic contraction of guinea pig ileum
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 9.02 | 10.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318812 | — | — | 2 | 10.92 |
| CHEMBL320611 | — | — | 1 | 10.46 |
| CHEMBL321214 | — | — | 2 | 9.52 |
| CHEMBL326640 | — | — | 2 | 8.45 |
| CHEMBL110339 | — | — | 1 | 8.44 |
| CHEMBL110808 | — | — | 2 | 8.32 |
| CHEMBL322582 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318812 | — | Kd | = | 0.01202 | nM | 10.92 |
| CHEMBL320611 | — | Kd | = | 0.03467 | nM | 10.46 |
| CHEMBL321214 | — | Kd | = | 0.302 | nM | 9.52 |
| CHEMBL321214 | — | Kd | = | 0.4467 | nM | 9.35 |
| CHEMBL326640 | — | Kd | = | 3.548 | nM | 8.45 |
| CHEMBL326640 | — | Kd | = | 3.548 | nM | 8.45 |
| CHEMBL110339 | — | Kd | = | 3.631 | nM | 8.44 |
| CHEMBL110808 | — | Kd | = | 4.786 | nM | 8.32 |
| CHEMBL110808 | — | Kd | = | 5.37 | nM | 8.27 |
| CHEMBL322582 | — | Kd | = | 9.12 | nM | 8.04 |
| CHEMBL318812 | — | Kd | = | 0.007762 | nM | - |