Muscarinic acetylcholine receptor M2 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P10980. Use UniProt P10980 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P10980 as the stable identity anchor, then attach disease evidence before program review.
Muscarinic acetylcholine receptor M2
Review this target as Muscarinic acetylcholine receptor M2, mapped to UniProt P10980. Sequence length is 466 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M2 as ChEMBL target CHEMBL309, mapped to UniProt P10980. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Muscarinic acetylcholine receptor M2 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P10980 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M2 |
| UniProt Accession | P10980 |
| Component Type | Protein |
| Sequence Length | 466 aa |
Muscarinic acetylcholine receptor M2
Review this target as Muscarinic acetylcholine receptor M2, mapped to UniProt P10980. Sequence length is 466 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3298595 | 10.57 | Ki | 0.027 | Preclinical |
| CHEMBL558910 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL3298599 | 10.28 | Ki | 0.053 | Preclinical |
| CHEMBL119294 | 10.19 | Ki | 0.065 | Preclinical |
| CHEMBL21812 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL3298596 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL47650 | 9.89 | Ki | 0.13 | Preclinical |
| CHEMBL3545181 | 9.82 | Ki | 0.15 | Approved |
| CHEMBL321214 | 9.75 | Ki | 0.177 | Preclinical |
| CHEMBL12980 | 9.74 | Ki | 0.18 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 62 | 201 | 7.3 |
| tissue-based format | 33 | 134 | 6.5 |
| assay format | 30 | 129 | 6.8 |
| cell membrane format | 12 | 58 | 6.5 |
| cell-based format | 7 | 15 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 17 | 6 | 5.5 |
| tissue-based format | 6 | 7 | 5.6 |
| assay format | 5 | 6 | 6.7 |
| organism-based format | 3 | 0 | — |
| single protein format | 2 | 1 | 5.2 |
| cell membrane format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 2 | 7.3 |