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Compound Detail

CHEMBL119294

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Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1

Basic Information

ChEMBL ID CHEMBL119294
Phase Preclinical
Structure Type MOL
InChI Key BUCSERUOVJCXTC-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

618.8
MW (Da)
4.77
ALogP
8
HBA
0
HBD
94.6
PSA (Ų)
0.39
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H38N2O7S
MW 618.75
Aromatic Rings 3
Heavy Atoms 44
NP-Likeness -0.77

Activity Summary

Ki 1 meas. best 10.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 10.19 10.19 0.1 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Muscarinic acetylcholine receptor M2 Ki = 0.065 nM 10.19 Binding affinity towards Muscarinic acetylcholine receptor M2 12419388

Literature References

PubMed DOI Target Context # Activities
12419388 10.1016/s0960-894x(02)00742-4 Muscarinic acetylcholine receptor M2 1
12419388 10.1016/s0960-894x(02)00742-4 Muscarinic receptor M1 and M2 1
12419388 10.1016/s0960-894x(02)00742-4 Muscarinic receptor M2 and M3 1

Data from ChEMBL 36 via Core Engine