Assay Detail
Binding
CHEMBL745631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Muscarinic acetylcholine receptor M2
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.95 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119294 | — | — | 1 | 10.19 |
| CHEMBL332703 | — | — | 1 | 9.41 |
| CHEMBL324484 | — | — | 1 | 9.40 |
| CHEMBL117351 | — | — | 1 | 9.36 |
| CHEMBL118391 | — | — | 1 | 9.29 |
| CHEMBL331214 | — | — | 1 | 9.28 |
| CHEMBL119131 | — | — | 1 | 9.28 |
| CHEMBL116777 | — | — | 1 | 9.27 |
| CHEMBL117414 | — | — | 1 | 9.17 |
| CHEMBL326561 | — | — | 1 | 9.14 |
| CHEMBL324116 | — | — | 1 | 9.11 |
| CHEMBL326057 | — | — | 1 | 9.07 |
| CHEMBL326990 | — | — | 1 | 9.05 |
| CHEMBL117817 | — | — | 1 | 9.00 |
| CHEMBL332702 | — | — | 1 | 8.96 |
| CHEMBL323850 | — | — | 1 | 8.92 |
| CHEMBL116781 | — | — | 1 | 8.85 |
| CHEMBL117797 | — | — | 1 | 8.82 |
| CHEMBL115681 | — | — | 1 | 8.80 |
| CHEMBL119168 | — | — | 1 | 8.74 |
| CHEMBL325451 | — | — | 1 | 8.64 |
| CHEMBL115807 | — | — | 1 | 8.60 |
| CHEMBL324832 | — | — | 1 | 8.32 |
| CHEMBL115642 | — | — | 1 | 7.75 |
| CHEMBL116404 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119294 | — | Ki | = | 0.065 | nM | 10.19 |
| CHEMBL332703 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL324484 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL117351 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL118391 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL331214 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL119131 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL116777 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL117414 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL326561 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL324116 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL326057 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL326990 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL117817 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL332702 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL323850 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL116781 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL117797 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL115681 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL119168 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL325451 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL115807 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL324832 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL115642 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL116404 | — | Ki | = | 51.0 | nM | 7.29 |