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Compound Detail

CHEMBL117797

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COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6N)CC5)CC4)OCCO3)cc2)cc1

Basic Information

ChEMBL ID CHEMBL117797
Phase Preclinical
Structure Type MOL
InChI Key CRBMSEWZNVIOAU-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

605.8
MW (Da)
4.33
ALogP
8
HBA
1
HBD
111.4
PSA (Ų)
0.40
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H39N3O6S
MW 605.76
Aromatic Rings 3
Heavy Atoms 43
NP-Likeness -0.63

Activity Summary

Ki 1 meas. best 8.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 8.82 8.82 1.5 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Muscarinic acetylcholine receptor M2 Ki = 1.5 nM 8.82 Binding affinity towards Muscarinic acetylcholine receptor M2 12419388

Literature References

PubMed DOI Target Context # Activities
12419388 10.1016/s0960-894x(02)00742-4 Muscarinic acetylcholine receptor M2 1
12419388 10.1016/s0960-894x(02)00742-4 Muscarinic receptor M1 and M2 1
12419388 10.1016/s0960-894x(02)00742-4 Muscarinic receptor M2 and M3 1
12419388 10.1016/s0960-894x(02)00742-4 ADMET 1

Data from ChEMBL 36 via Core Engine