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Evidence Snapshot

Muscarinic acetylcholine receptor M2

CHEMBL309 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:04Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL309
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Muscarinic acetylcholine receptor M2 as ChEMBL target CHEMBL309, mapped to UniProt P10980. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Muscarinic acetylcholine receptor M2
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL309
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P10980
Muscarinic acetylcholine receptor M2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Muscarinic acetylcholine receptor M2 matters

As of 2026-09-13

Muscarinic acetylcholine receptor M2 is reviewed as Muscarinic acetylcholine receptor M2 (UniProt P10980); the current evidence base includes 22 approved drugs, 692 compounds, and 178 assays, with lead potency reaching pChEMBL 10.6.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 22 approved drugs, 692 compounds, and 178 assays for this target. The dominant activity type is KI. CHEMBL3298595 is the current potency anchor at pChEMBL 10.6.

Use CHEMBL3298595 as the tractability anchor when discussing potency (pChEMBL 10.6).

Activity source · ChEMBL 36 via Core Engine
22 approved pChEMBL 10.6
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Muscarinic acetylcholine receptor M2 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P10980, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

692
Total Compounds
178
Total Assays
22
Approved Drugs
IC50: 218.0, KI: 499.0, EC50: 33.0, KD: 49.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3298595
 10.6 Ki —
No preferred name
CHEMBL558910
 10.5 Ki —
No preferred name
CHEMBL3298599
 10.3 Ki —
No preferred name
CHEMBL119294
 10.2 Ki —
No preferred name
CHEMBL21812
 10.0 Ki —

Approved Drugs

Structure Compound First Approval
XANOMELINE
CHEMBL21536
 2024
TIOTROPIUM BROMIDE
CHEMBL3545181
 2004
DARIFENACIN
CHEMBL1346
 2004
SOLIFENACIN
CHEMBL1734
 2004
TOLTERODINE
CHEMBL1382
 1998
CLOZAPINE
CHEMBL42
 1989
METHACHOLINE
CHEMBL978
 1986
SCOPOLAMINE
CHEMBL569713
 1979
OXYBUTYNIN
CHEMBL1231
 1975
CARBACHOL
CHEMBL14
 1972
HALOPERIDOL
CHEMBL54
 1967
ATROPINE
CHEMBL517712
 1960
BENZTROPINE
CHEMBL1201203
 1954
DICYCLOMINE
CHEMBL1123
 1950
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:04Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL309