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Compound Detail

CHEMBL21812

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C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2.[I-]

Basic Information

ChEMBL ID CHEMBL21812
Phase Preclinical
Structure Type MOL
InChI Key PJUALTWRJIYAHC-LPOVJKNVSA-M
Parent Compound CHEMBL1178341
Active Moiety CHEMBL1178341
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

358.5
MW (Da)
3.24
ALogP
3
HBA
1
HBD
46.5
PSA (Ų)
0.66
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H32INO3
MW 485.41
Aromatic Rings 1
Heavy Atoms 26
NP-Likeness 0.50

Activity Summary

Ki 4 meas. best 11.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL2672
Ki 11.0 11.0 0.0 1
Muscarinic acetylcholine receptor M1
CHEMBL276
Ki 10.7 10.7 0.0 1
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 10.0 10.0 0.1 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Ki 9.92 9.92 0.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9016336 10.1021/jm960374w Rattus norvegicus 36
9016336 10.1021/jm960374w ADMET 16
9016336 10.1021/jm960374w Muscarinic acetylcholine receptor M1 2
9016336 10.1021/jm960374w Muscarinic acetylcholine receptor M2 1
9016336 10.1021/jm960374w Muscarinic acetylcholine receptor M3 1

Data from ChEMBL 36 via Core Engine