Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL2672 Target Snapshot

Muscarinic acetylcholine receptor M1 · SINGLE PROTEIN · Bos taurus

Back to Search Search this target Browse approvals Evidence Card
35Compounds
9Assays
2Approved Drugs
39.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q8WMX0. Use UniProt Q8WMX0 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8WMX0 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Muscarinic acetylcholine receptor M1 as ChEMBL target CHEMBL2672, mapped to UniProt Q8WMX0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Muscarinic acetylcholine receptor M1
SINGLE PROTEIN · Bos taurus
As of 2026-09-13
ChEMBL target ID
CHEMBL2672
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q8WMX0
Muscarinic receptor M1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Muscarinic acetylcholine receptor M1 is the right protein anchor across sources, using UniProt Q8WMX0 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMuscarinic acetylcholine receptor M1
Target TypeSINGLE PROTEIN
OrganismBos taurus
UniProtQ8WMX0
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMuscarinic receptor M1
UniProt AccessionQ8WMX0
Component TypeProtein
Sequence Length139 aa

Muscarinic receptor M1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Muscarinic acetylcholine receptor M1, mapped to UniProt Q8WMX0. ChEMBL maps the protein component as Muscarinic receptor M1. Sequence length is 139 aa.

Mapped IDQ8WMX0
Review nameMuscarinic acetylcholine receptor M1
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

2
Approved
2
Phase II
Assay Mix

Activity Type Distribution

KI39.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL21812 11.0 Ki 0.01 Preclinical
CHEMBL21905 10.7 Ki 0.02 Preclinical
CHEMBL297276 9.96 Ki 0.11 Preclinical
CHEMBL558910 9.72 Ki 0.19 Preclinical
CHEMBL296895 9.7 Ki 0.2 Preclinical
CHEMBL517712 9.7 Ki 0.2 Approved
CHEMBL549577 9.7 Ki 0.2 Preclinical
CHEMBL12980 9.66 Ki 0.22 Preclinical
CHEMBL296633 9.59 Ki 0.26 Preclinical
CHEMBL2115342 9.54 Ki 0.29 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
1
5.5
0
6.0
3
6.5
3
7.0
7
7.5
5
8.0
3
8.5
5
9.0
8
9.5
pChEMBL
Approved Drugs

Approved Drugs

SCOPOLAMINE
CHEMBL569713
Approved 1979
Properties Compare Identifier
ATROPINE
CHEMBL517712
Approved 1960
Properties Compare Identifier
Assay Landscape

Assay Landscape

9
Total Assays
34
Tested Compounds
1
Assay Types
Binding — 9 assays, 34 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 5 17 7.9
assay format 2 13 8.7
cell membrane format 1 3 10.4
single protein format 1 1 8.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine