Assay Detail
Binding
CHEMBL744097
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Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Stereoselective synthesis and biodistribution of potent [11C]-labeled antagonists for positron emission tomography imaging of muscarinic receptors in the airways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.35 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21812 | — | — | 1 | 10.00 |
| CHEMBL21905 | — | — | 1 | 9.68 |
| CHEMBL1398637 | — | — | 1 | 9.37 |
| CHEMBL569713 | SCOPOLAMINE | 4.0 | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21812 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL21905 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL1398637 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL569713 | SCOPOLAMINE | Ki | = | 4.57 | nM | 8.34 |