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Compound Detail

CHEMBL1398637

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C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2

Basic Information

ChEMBL ID CHEMBL1398637
Phase Preclinical
Structure Type MOL
InChI Key HOOSGZJRQIVJSZ-GTPZEUEISA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

352.4
MW (Da)
2.70
ALogP
3
HBA
1
HBD
46.5
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C22H26NO3+
MW 352.45
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness 0.40

Activity Summary

Ki 3 meas. best 9.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
Ki 9.89 9.89 0.1 1
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 9.37 9.37 0.4 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Ki 9.19 9.19 0.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9016336 10.1021/jm960374w Muscarinic acetylcholine receptor M1 1
9016336 10.1021/jm960374w Muscarinic acetylcholine receptor M2 1
9016336 10.1021/jm960374w Muscarinic acetylcholine receptor M3 1

Data from ChEMBL 36 via Core Engine