Assay Detail
Binding
CHEMBL743827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Muscarinic acetylcholine receptor M3 was determined in guinea pig ileum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL5498) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Stereoselective synthesis and biodistribution of potent [11C]-labeled antagonists for positron emission tomography imaging of muscarinic receptors in the airways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.08 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21905 | — | — | 1 | 10.05 |
| CHEMBL21812 | — | — | 1 | 9.92 |
| CHEMBL1398637 | — | — | 1 | 9.19 |
| CHEMBL76897 | 4-DAMP | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21905 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL21812 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL1398637 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL76897 | 4-DAMP | Ki | = | 66.9 | nM | 7.17 |