Evidence Snapshot

Muscarinic acetylcholine receptor M3

CHEMBL5498 SINGLE PROTEIN Cavia porcellus

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T08:18:00Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 13, 2026, 5:18 PM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL5498

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Muscarinic acetylcholine receptor M3 as ChEMBL target CHEMBL5498, mapped to UniProt Q8VH26. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

Muscarinic acetylcholine receptor M3

SINGLE PROTEIN · Cavia porcellus

As of 2026-09-13

ChEMBL target ID

CHEMBL5498

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

UniProt accession

Q8VH26

Muscarinic acetylcholine receptor

UniProt accession via ChEMBL component mapping As of 2026-09-13

www.uniprot.org

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Muscarinic acetylcholine receptor M3 matters

As of 2026-09-13

Muscarinic acetylcholine receptor M3 is reviewed as Muscarinic acetylcholine receptor (UniProt Q8VH26); the current evidence base includes 10 approved drugs, 804 compounds, and 157 assays, with lead potency reaching pChEMBL 10.7.

Protein context

Muscarinic acetylcholine receptor

Muscarinic acetylcholine receptor Sequence length is 587 aa.

Review this target as Muscarinic acetylcholine receptor M3, mapped to UniProt Q8VH26. ChEMBL maps the protein component as Muscarinic acetylcholine receptor. Sequence length is 587 aa.

Protein source · UniProt accession via ChEMBL component mapping

UniProt Q8VH26 Protein

Disease context

Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record

Activity base

Portfolio and assay base

ChEMBL currently tracks 10 approved drugs, 804 compounds, and 157 assays for this target. The dominant activity type is KD. CHEMBL3087240 is the current potency anchor at pChEMBL 10.7.

Use CHEMBL3087240 as the tractability anchor when discussing potency (pChEMBL 10.7).

Activity source · ChEMBL 36 via Core Engine

10 approved pChEMBL 10.7

Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

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Review-ready Target Rationale

One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Muscarinic acetylcholine receptor M3 matters before drilling into raw source blocks.

Jump to Review Rationale

Need stable protein naming or accession mapping?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q8VH26, not just the summarized rationale.

Open Protein Context

Need disease fit or evidence level for program framing?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

804

Total Compounds

157

Total Assays

Approved Drugs

IC50: 34.0, KI: 67.0, EC50: 37.0, KD: 222.0

Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Compound	pChEMBL	Type	Phase
No preferred name CHEMBL3087240	10.7	Kd	—
No preferred name CHEMBL92421	10.3	EC50	—
No preferred name CHEMBL3087368	10.1	Kd	—
No preferred name CHEMBL3087236	10.1	Kd	—
No preferred name CHEMBL21905	10.1	Ki	—