Assay Detail
Binding
CHEMBL749219
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in guinea pig ileum
19
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.75 | 10.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320611 | — | — | 3 | 10.27 |
| CHEMBL318812 | — | — | 1 | 9.35 |
| CHEMBL321214 | — | — | 1 | 9.32 |
| CHEMBL326640 | — | — | 1 | 8.09 |
| CHEMBL110339 | — | — | 1 | 8.02 |
| CHEMBL322582 | — | — | 1 | 7.89 |
| CHEMBL110808 | — | — | 1 | 7.72 |
| CHEMBL2113669 | — | — | 2 | 5.43 |
| CHEMBL111529 | — | — | 3 | 5.38 |
| CHEMBL326453 | — | — | 1 | 5.34 |
| CHEMBL607175 | — | — | 1 | 5.11 |
| CHEMBL325322 | — | — | 3 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320611 | — | Ki | = | 0.054 | nM | 10.27 |
| CHEMBL320611 | — | Ki | = | 0.279 | nM | 9.55 |
| CHEMBL318812 | — | Ki | = | 0.449 | nM | 9.35 |
| CHEMBL321214 | — | Ki | = | 0.475 | nM | 9.32 |
| CHEMBL326640 | — | Ki | = | 8.21 | nM | 8.09 |
| CHEMBL110339 | — | Ki | = | 9.64 | nM | 8.02 |
| CHEMBL322582 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL320611 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL110808 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL2113669 | — | Ki | = | 3750.0 | nM | 5.43 |
| CHEMBL111529 | — | Ki | = | 4190.0 | nM | 5.38 |
| CHEMBL326453 | — | Ki | = | 4570.0 | nM | 5.34 |
| CHEMBL607175 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL111529 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL325322 | — | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL325322 | — | Ki | = | 11900.0 | nM | 4.92 |
| CHEMBL2113669 | — | Ki | = | 12900.0 | nM | 4.89 |
| CHEMBL111529 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL325322 | — | Ki | = | 38100.0 | nM | 4.42 |