Assay Detail
Binding
CHEMBL752312
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Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in rat heart.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.67 | 9.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320611 | — | — | 1 | 9.71 |
| CHEMBL321214 | — | — | 1 | 9.53 |
| CHEMBL318812 | — | — | 1 | 9.52 |
| CHEMBL326640 | — | — | 1 | 8.26 |
| CHEMBL322582 | — | — | 1 | 8.03 |
| CHEMBL110339 | — | — | 1 | 7.89 |
| CHEMBL110808 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320611 | — | Ki | = | 0.196 | nM | 9.71 |
| CHEMBL321214 | — | Ki | = | 0.297 | nM | 9.53 |
| CHEMBL318812 | — | Ki | = | 0.302 | nM | 9.52 |
| CHEMBL326640 | — | Ki | = | 5.49 | nM | 8.26 |
| CHEMBL322582 | — | Ki | = | 9.28 | nM | 8.03 |
| CHEMBL110339 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL110808 | — | Ki | = | 16.9 | nM | 7.77 |