Assay Detail
Binding
CHEMBL749927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]pirenzepine binding against muscarinic acetylcholine receptor in rat brain.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.95 | 9.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320611 | — | — | 1 | 9.93 |
| CHEMBL321214 | — | — | 1 | 9.78 |
| CHEMBL318812 | — | — | 1 | 9.71 |
| CHEMBL326640 | — | — | 1 | 8.54 |
| CHEMBL110808 | — | — | 1 | 8.24 |
| CHEMBL110339 | — | — | 1 | 7.90 |
| CHEMBL322582 | — | — | 1 | 7.55 |
| CHEMBL111529 | — | — | 1 | 5.01 |
| CHEMBL325322 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320611 | — | Ki | = | 0.118 | nM | 9.93 |
| CHEMBL321214 | — | Ki | = | 0.166 | nM | 9.78 |
| CHEMBL318812 | — | Ki | = | 0.197 | nM | 9.71 |
| CHEMBL326640 | — | Ki | = | 2.87 | nM | 8.54 |
| CHEMBL110808 | — | Ki | = | 5.73 | nM | 8.24 |
| CHEMBL110339 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL322582 | — | Ki | = | 27.9 | nM | 7.55 |
| CHEMBL111529 | — | Ki | = | 9810.0 | nM | 5.01 |
| CHEMBL325322 | — | Ki | = | 12500.0 | nM | 4.90 |