Assay Detail
Binding
CHEMBL752311
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Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in rat brain.
22
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.94 | 10.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320611 | — | — | 3 | 10.53 |
| CHEMBL321214 | — | — | 1 | 9.65 |
| CHEMBL318812 | — | — | 1 | 9.60 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.47 |
| CHEMBL326640 | — | — | 1 | 8.72 |
| CHEMBL110808 | — | — | 1 | 8.39 |
| CHEMBL110339 | — | — | 1 | 8.38 |
| CHEMBL322582 | — | — | 1 | 8.02 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 6.00 |
| CHEMBL326453 | — | — | 1 | 5.45 |
| CHEMBL111529 | — | — | 3 | 5.43 |
| CHEMBL2113669 | — | — | 2 | 5.33 |
| CHEMBL325322 | — | — | 3 | 5.19 |
| CHEMBL607175 | — | — | 1 | 5.00 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320611 | — | Ki | = | 0.0297 | nM | 10.53 |
| CHEMBL320611 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL321214 | — | Ki | = | 0.224 | nM | 9.65 |
| CHEMBL318812 | — | Ki | = | 0.254 | nM | 9.60 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.337 | nM | 9.47 |
| CHEMBL326640 | — | Ki | = | 1.89 | nM | 8.72 |
| CHEMBL110808 | — | Ki | = | 4.07 | nM | 8.39 |
| CHEMBL110339 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL320611 | — | Ki | = | 6.36 | nM | 8.20 |
| CHEMBL322582 | — | Ki | = | 9.53 | nM | 8.02 |
| CHEMBL550 | PILOCARPINE | Ki | = | 1010.0 | nM | 6.00 |
| CHEMBL326453 | — | Ki | = | 3530.0 | nM | 5.45 |
| CHEMBL111529 | — | Ki | = | 3730.0 | nM | 5.43 |
| CHEMBL2113669 | — | Ki | = | 4710.0 | nM | 5.33 |
| CHEMBL325322 | — | Ki | = | 6470.0 | nM | 5.19 |
| CHEMBL111529 | — | Ki | = | 7530.0 | nM | 5.12 |
| CHEMBL111529 | — | Ki | = | 8560.0 | nM | 5.07 |
| CHEMBL325322 | — | Ki | = | 8550.0 | nM | 5.07 |
| CHEMBL607175 | — | Ki | = | 10100.0 | nM | 5.00 |
| CHEMBL14 | CARBACHOL | Ki | = | 18800.0 | nM | 4.73 |
| CHEMBL2113669 | — | Ki | = | 19100.0 | nM | 4.72 |
| CHEMBL325322 | — | Ki | = | 23000.0 | nM | 4.64 |