Assay Detail
Binding
CHEMBL1787508
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Inhibition of JNK3 using biotinylated ATF2 and ATP substrates by HTRF assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.04 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783587 | — | — | 1 | 7.22 |
| CHEMBL1783588 | — | — | 1 | 7.10 |
| CHEMBL1783594 | — | — | 1 | 6.96 |
| CHEMBL1233749 | — | — | 1 | 6.80 |
| CHEMBL1784096 | — | — | 1 | 6.70 |
| CHEMBL1783590 | — | — | 1 | 6.68 |
| CHEMBL1784089 | — | — | 1 | 6.60 |
| CHEMBL1784097 | — | — | 1 | 6.54 |
| CHEMBL1783492 | — | — | 1 | 6.51 |
| CHEMBL1784086 | — | — | 1 | 6.48 |
| CHEMBL1783592 | — | — | 1 | 6.46 |
| CHEMBL1783589 | — | — | 1 | 6.39 |
| CHEMBL1783591 | — | — | 1 | 6.28 |
| CHEMBL1784087 | — | — | 1 | 6.27 |
| CHEMBL1783596 | — | — | 1 | 6.21 |
| CHEMBL1784093 | — | — | 1 | 6.09 |
| CHEMBL1784084 | — | — | 1 | 6.05 |
| CHEMBL1784088 | — | — | 1 | 6.02 |
| CHEMBL1783593 | — | — | 1 | 6.00 |
| CHEMBL1784092 | — | — | 1 | 6.00 |
| CHEMBL1420552 | — | — | 1 | 5.96 |
| CHEMBL1784090 | — | — | 1 | 5.96 |
| CHEMBL1784083 | — | — | 1 | 5.92 |
| CHEMBL1784091 | — | — | 1 | 5.85 |
| CHEMBL1783493 | — | — | 1 | 5.75 |
| CHEMBL1783583 | — | — | 1 | 5.70 |
| CHEMBL1783498 | — | — | 1 | 5.70 |
| CHEMBL1784085 | — | — | 1 | 5.66 |
| CHEMBL1783494 | — | — | 1 | 5.64 |
| CHEMBL1783595 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783587 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1783588 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1783594 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1233749 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1784096 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1783590 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1784089 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1784097 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1783492 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1784086 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1783592 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1783589 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1783591 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1784087 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1783596 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1784093 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1784084 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1784088 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1783593 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1784092 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1420552 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1784090 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1784083 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1784091 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1783493 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1783583 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1783498 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1784085 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1783494 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1783595 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1783495 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1783497 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1783584 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1783496 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1784082 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1783597 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1783586 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1783585 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1783491 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1783490 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1783489 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1784098 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1784095 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1784094 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1783598 | — | IC50 | > | 20000.0 | nM | - |