Assay Detail
Binding
CHEMBL1787586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]TCP from NMDA receptor PCP binding site in rat brain
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.96 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305904 | ETOXADROL | 2.0 | 1 | 6.97 |
| CHEMBL1165411 | DEXOXADROL | 2.0 | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305904 | ETOXADROL | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL1165411 | DEXOXADROL | Ki | = | 112.0 | nM | 6.95 |