Assay Detail
Binding
CHEMBL1787617
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Inhibition of human renin
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potential virtual lead identification in the discovery of renin inhibitors: application of ligand and structure-based pharmacophore modeling approaches.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.81 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783181 | — | — | 1 | 9.80 |
| CHEMBL1783182 | — | — | 1 | 9.40 |
| CHEMBL1783183 | — | — | 1 | 9.33 |
| CHEMBL1639 | ALISKIREN | 4.0 | 1 | 9.22 |
| CHEMBL1783184 | — | — | 1 | 9.15 |
| CHEMBL1783185 | — | — | 1 | 9.10 |
| CHEMBL1783186 | — | — | 1 | 9.05 |
| CHEMBL1783187 | — | — | 1 | 9.00 |
| CHEMBL1783188 | — | — | 1 | 8.52 |
| CHEMBL239496 | — | — | 1 | 8.15 |
| CHEMBL1234021 | — | — | 1 | 7.57 |
| CHEMBL1783189 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783181 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL1783182 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1783183 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL1639 | ALISKIREN | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1783184 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1783185 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1783186 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1783187 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1783188 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL239496 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL1234021 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1783189 | — | IC50 | = | 37.0 | nM | 7.43 |