Compound Detail
CHEMBL1783181
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Cc1cc(Cl)c(OCCOc2ccc(C3=C(C(=O)N(Cc4cccc(C)c4C)C4CC4)C4CNCC(C3)N4)cc2)c(Cl)c1
Basic Information
| ChEMBL ID | CHEMBL1783181 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VKBBVOVNGWGZCA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
620.6
MW (Da)
6.65
ALogP
5
HBA
2
HBD
62.8
PSA (Ų)
0.25
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Renin CHEMBL286 | IC50 | 9.8 | 9.8 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Renin | IC50 | = | 0.16 | nM | 9.8 | Inhibition of human renin | 21497958 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21497958 | 10.1016/j.ejmech.2011.03.035 | Renin | 1 |
Data from ChEMBL 36 via Core Engine