Assay Detail
Functional
CHEMBL1787642
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Antiproliferative activity against mouse BA/F3 cells expressing wild type BCR-ABL
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.38 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236871 | — | — | 1 | 9.21 |
| CHEMBL1784638 | — | — | 1 | 9.19 |
| CHEMBL1784641 | — | — | 1 | 9.17 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 8.92 |
| CHEMBL1784637 | — | — | 1 | 8.89 |
| CHEMBL1784634 | — | — | 1 | 8.89 |
| CHEMBL1784635 | — | — | 1 | 8.77 |
| CHEMBL1784627 | — | — | 1 | 8.66 |
| CHEMBL1784628 | — | — | 1 | 8.60 |
| CHEMBL1784629 | — | — | 1 | 8.59 |
| CHEMBL1784640 | — | — | 1 | 8.55 |
| CHEMBL1784626 | — | — | 1 | 8.51 |
| CHEMBL1784636 | — | — | 1 | 8.41 |
| CHEMBL1784625 | — | — | 1 | 8.39 |
| CHEMBL1784639 | — | — | 1 | 8.12 |
| CHEMBL1784633 | — | — | 1 | 8.07 |
| CHEMBL1784632 | — | — | 1 | 7.37 |
| CHEMBL1784630 | — | — | 1 | 6.71 |
| CHEMBL1784631 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236871 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL1784638 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL1784641 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1784637 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1784634 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1784635 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1784627 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1784628 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1784629 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1784640 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1784626 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1784636 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1784625 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1784639 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL1784633 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1784632 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1784630 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL1784631 | — | IC50 | = | 730.0 | nM | 6.14 |