Assay Detail
Functional
CHEMBL1787644
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Antiproliferative activity against BCR-ABL-negative parental mouse BA/F3 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.77 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1784641 | — | — | 1 | 7.01 |
| CHEMBL1784630 | — | — | 1 | 6.22 |
| CHEMBL1784634 | — | — | 1 | 6.10 |
| CHEMBL1784629 | — | — | 1 | 5.99 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.91 |
| CHEMBL1784640 | — | — | 1 | 5.90 |
| CHEMBL1236871 | — | — | 1 | 5.88 |
| CHEMBL1784635 | — | — | 1 | 5.80 |
| CHEMBL1784636 | — | — | 1 | 5.79 |
| CHEMBL1784628 | — | — | 1 | 5.78 |
| CHEMBL1784633 | — | — | 1 | 5.75 |
| CHEMBL1784627 | — | — | 1 | 5.75 |
| CHEMBL1784625 | — | — | 1 | 5.69 |
| CHEMBL1784638 | — | — | 1 | 5.62 |
| CHEMBL1784626 | — | — | 1 | 5.55 |
| CHEMBL1784637 | — | — | 1 | 5.51 |
| CHEMBL1784632 | — | — | 1 | 5.25 |
| CHEMBL1784631 | — | — | 1 | 5.18 |
| CHEMBL1784639 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1784641 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1784630 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL1784634 | — | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL1784629 | — | IC50 | = | 1021.0 | nM | 5.99 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1219.0 | nM | 5.91 |
| CHEMBL1784640 | — | IC50 | = | 1269.0 | nM | 5.90 |
| CHEMBL1236871 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL1784635 | — | IC50 | = | 1583.0 | nM | 5.80 |
| CHEMBL1784636 | — | IC50 | = | 1603.0 | nM | 5.79 |
| CHEMBL1784628 | — | IC50 | = | 1659.0 | nM | 5.78 |
| CHEMBL1784633 | — | IC50 | = | 1793.0 | nM | 5.75 |
| CHEMBL1784627 | — | IC50 | = | 1787.0 | nM | 5.75 |
| CHEMBL1784625 | — | IC50 | = | 2038.0 | nM | 5.69 |
| CHEMBL1784638 | — | IC50 | = | 2378.0 | nM | 5.62 |
| CHEMBL1784626 | — | IC50 | = | 2818.0 | nM | 5.55 |
| CHEMBL1784637 | — | IC50 | = | 3093.0 | nM | 5.51 |
| CHEMBL1784632 | — | IC50 | = | 5647.0 | nM | 5.25 |
| CHEMBL1784631 | — | IC50 | = | 6549.0 | nM | 5.18 |
| CHEMBL1784639 | — | IC50 | = | 10000.0 | nM | 5.00 |