Assay Detail
Binding
CHEMBL1787945
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Inhibition of PYK2 by PYK2-LI-COR cellular assay
13
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.30 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2029181 | — | — | 3 | 8.00 |
| CHEMBL2448536 | — | — | 1 | 7.62 |
| CHEMBL2029180 | — | — | 3 | 7.54 |
| CHEMBL2029182 | — | — | 1 | 7.47 |
| CHEMBL519418 | — | — | 1 | 7.22 |
| CHEMBL472212 | — | — | 1 | 7.20 |
| CHEMBL509485 | — | — | 1 | 7.06 |
| CHEMBL1783837 | — | — | 1 | 7.02 |
| CHEMBL2029183 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2029181 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2029181 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2448536 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2029180 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2029182 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2029181 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL519418 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL472212 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2029180 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL509485 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1783837 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2029180 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL2029183 | — | IC50 | = | 320.0 | nM | 6.50 |