Assay Detail
Binding
CHEMBL1787961
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Inhibition of NHE1-mediated rat platelet swelling
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.55 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783852 | — | — | 1 | 8.44 |
| CHEMBL1783857 | — | — | 1 | 8.35 |
| CHEMBL1783849 | — | — | 1 | 7.96 |
| CHEMBL1783830 | — | — | 1 | 7.94 |
| CHEMBL1783853 | — | — | 1 | 7.85 |
| CHEMBL1783856 | — | — | 1 | 7.82 |
| CHEMBL1783854 | — | — | 1 | 7.73 |
| CHEMBL1783847 | — | — | 1 | 7.44 |
| CHEMBL1783848 | — | — | 1 | 7.44 |
| CHEMBL1783850 | — | — | 1 | 7.39 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 7.19 |
| CHEMBL1783851 | — | — | 1 | 6.61 |
| CHEMBL1783855 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783852 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1783857 | — | IC50 | = | 4.48 | nM | 8.35 |
| CHEMBL1783849 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL1783830 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL1783853 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL1783856 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1783854 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL1783847 | — | IC50 | = | 36.4 | nM | 7.44 |
| CHEMBL1783848 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL1783850 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1783851 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL1783855 | — | IC50 | = | 1150.0 | nM | 5.94 |