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Assay Detail

CHEMBL1794460

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Binding
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for inhibitors of TLR9-MyD88 binding. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504734, AID504750, AID540250, AID540251]
ChEMBL ↗
235
Total Activities
234
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Toll-like receptor 9 (CHEMBL5804) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 235 5.15 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1790039 — — 1 5.82
CHEMBL429095 — — 1 5.73
CHEMBL131037 — — 1 5.58
CHEMBL1699845 — — 1 5.58
CHEMBL1865393 — — 1 5.56
CHEMBL1585390 — — 1 5.53
CHEMBL1991303 — — 1 5.52
CHEMBL1712082 — — 1 5.52
CHEMBL1360031 — — 1 5.51
CHEMBL1732235 — — 1 5.51
CHEMBL1418079 — — 1 5.51
CHEMBL1554784 — — 1 5.49
CHEMBL1342053 — — 1 5.49
CHEMBL1491686 — — 1 5.49
CHEMBL1526126 — — 1 5.48
CHEMBL1460029 — — 1 5.47
CHEMBL1984244 — — 1 5.47
CHEMBL1520346 — — 1 5.47
CHEMBL1526855 — — 1 5.46
CHEMBL1500409 — — 1 5.46
CHEMBL1570958 — — 1 5.46
CHEMBL1470904 — — 1 5.46
CHEMBL1385690 — — 1 5.45
CHEMBL1472131 — — 1 5.45
CHEMBL1499951 — — 1 5.44
CHEMBL1308404 — — 1 5.43
CHEMBL1611182 — — 1 5.42
CHEMBL1899958 — — 1 5.42
CHEMBL505670 — — 1 5.41
CHEMBL2005437 — — 1 5.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1790039 — IC50 = 1509.0 nM 5.82
CHEMBL429095 — IC50 = 1869.0 nM 5.73
CHEMBL1699845 — IC50 = 2626.0 nM 5.58
CHEMBL131037 — IC50 = 2617.0 nM 5.58
CHEMBL1865393 — IC50 = 2775.0 nM 5.56
CHEMBL1585390 — IC50 = 2951.0 nM 5.53
CHEMBL1991303 — IC50 = 3008.0 nM 5.52
CHEMBL1712082 — IC50 = 3015.0 nM 5.52
CHEMBL1360031 — IC50 = 3069.0 nM 5.51
CHEMBL1418079 — IC50 = 3122.0 nM 5.51
CHEMBL1732235 — IC50 = 3117.0 nM 5.51
CHEMBL1342053 — IC50 = 3220.0 nM 5.49
CHEMBL1554784 — IC50 = 3213.0 nM 5.49
CHEMBL1491686 — IC50 = 3277.0 nM 5.49
CHEMBL1526126 — IC50 = 3337.0 nM 5.48
CHEMBL1520346 — IC50 = 3383.0 nM 5.47
CHEMBL1460029 — IC50 = 3371.0 nM 5.47
CHEMBL1984244 — IC50 = 3382.0 nM 5.47
CHEMBL1500409 — IC50 = 3457.0 nM 5.46
CHEMBL1526855 — IC50 = 3511.0 nM 5.46
CHEMBL1470904 — IC50 = 3499.0 nM 5.46
CHEMBL1570958 — IC50 = 3509.0 nM 5.46
CHEMBL1472131 — IC50 = 3593.0 nM 5.45
CHEMBL1385690 — IC50 = 3565.0 nM 5.45
CHEMBL1499951 — IC50 = 3656.0 nM 5.44
CHEMBL1308404 — IC50 = 3741.0 nM 5.43
CHEMBL1899958 — IC50 = 3826.0 nM 5.42
CHEMBL1611182 — IC50 = 3780.0 nM 5.42
CHEMBL2005437 — IC50 = 3914.0 nM 5.41
CHEMBL505670 — IC50 = 3916.0 nM 5.41
CHEMBL1731330 — IC50 = 3972.0 nM 5.40
CHEMBL1999049 — IC50 = 3976.0 nM 5.40
CHEMBL1725771 — IC50 = 4091.0 nM 5.39
CHEMBL1508593 — IC50 = 4061.0 nM 5.39
CHEMBL1704261 — IC50 = 4116.0 nM 5.39
CHEMBL1416020 — IC50 = 4128.0 nM 5.38
CHEMBL1458470 — IC50 = 4142.0 nM 5.38
CHEMBL1609419 — IC50 = 4219.0 nM 5.38
CHEMBL1436864 — IC50 = 4182.0 nM 5.38
CHEMBL1418162 — IC50 = 4142.0 nM 5.38
CHEMBL432044 — IC50 = 4186.0 nM 5.38
CHEMBL1416184 — IC50 = 4264.0 nM 5.37
CHEMBL1462613 — IC50 = 4251.0 nM 5.37
CHEMBL1303426 — IC50 = 4311.0 nM 5.37
CHEMBL1494120 — IC50 = 4467.0 nM 5.35
CHEMBL1513846 — IC50 = 4520.0 nM 5.34
CHEMBL1315948 — IC50 = 4596.0 nM 5.34
CHEMBL1532668 — IC50 = 4733.0 nM 5.33
CHEMBL1567159 — IC50 = 4634.0 nM 5.33
CHEMBL1319867 — IC50 = 4623.0 nM 5.33