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Compound Detail

CHEMBL1472131

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CCCCNc1ccc2c3c(cccc13)C(=O)N(CCCC)C2=O

Basic Information

ChEMBL ID CHEMBL1472131
Phase Preclinical
Structure Type MOL
InChI Key DXWHZJXKTHGHQF-UHFFFAOYSA-N
6
Targets
8
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

324.4
MW (Da)
4.45
ALogP
3
HBA
1
HBD
49.4
PSA (Ų)
0.60
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H24N2O2
MW 324.42
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -1.06

Activity Summary

IC50 6 meas. best 5.51
EC50 2 meas. best 5.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 5.77 5.77 1690.0 1
Beta Lactamase
CHEMBL1293246
IC50 5.51 5.05 3071.0 2
Toll-like receptor 9
CHEMBL5804
IC50 5.45 5.45 3593.0 1
Beta-lactamase
CHEMBL1293260
IC50 5.41 5.41 3892.0 1
HEK293
CHEMBL614818
EC50 4.92 4.92 12111.0 1
Beta-lactamase
CHEMBL1293244
IC50 4.43 4.43 37154.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1007/s00044-010-9384-4 Radical scavenging activity 1

Data from ChEMBL 36 via Core Engine