Assay Detail
Functional
CHEMBL1798225
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Inhibition of phenylephrine-induced vasoconstriction in Long Evans rat mesenteric arteries treated 45 mins before phenylephrine challenge
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Mesenteric artery |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.77 | 5.78 |
| IC20 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122 | ROFECOXIB | 4.0 | 2 | 5.78 |
| CHEMBL1797511 | — | — | 2 | 5.78 |
| CHEMBL1797512 | — | — | 2 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122 | ROFECOXIB | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL1797511 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL1797512 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL1797511 | — | IC20 | = | 1.01 | uM | - |
| CHEMBL1797512 | — | IC20 | = | 1.37 | uM | - |
| CHEMBL122 | ROFECOXIB | IC20 | = | 0.95 | uM | - |