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Assay Detail

CHEMBL1798342

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Binding
Inhibition of farnesyltransferase
ChEMBL ↗
133
Total Activities
133
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Insights into the structural requirements of farnesyltransferase inhibitors as potential anti-tumor agents based on 3D-QSAR CoMFA and CoMSIA models.
Puntambekar DS, Giridhar R, Yadav MR.
Eur J Med Chem (2008) 43 : 142 -154
PubMed 17448576 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 133 7.94 9.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL41748 — — 1 9.69
CHEMBL186617 — — 1 9.49
CHEMBL186906 — — 1 9.43
CHEMBL187807 — — 1 9.43
CHEMBL187128 — — 1 9.42
CHEMBL184330 — — 1 9.35
CHEMBL181748 — — 1 9.30
CHEMBL183953 — — 1 9.23
CHEMBL182171 — — 1 9.22
CHEMBL186927 — — 1 9.20
CHEMBL362881 — — 1 9.18
CHEMBL360525 — — 1 9.09
CHEMBL363041 — — 1 9.09
CHEMBL184916 — — 1 9.04
CHEMBL184537 — — 1 9.03
CHEMBL359959 — — 1 8.92
CHEMBL184568 — — 1 8.92
CHEMBL1796675 — — 1 8.89
CHEMBL179902 — — 1 8.88
CHEMBL183832 — — 1 8.88
CHEMBL183719 — — 1 8.88
CHEMBL365289 — — 1 8.88
CHEMBL362519 — — 1 8.88
CHEMBL362750 — — 1 8.85
CHEMBL1796645 — — 1 8.82
CHEMBL183276 — — 1 8.82
CHEMBL186715 — — 1 8.82
CHEMBL183097 — — 1 8.76
CHEMBL361353 — — 1 8.76
CHEMBL362338 — — 1 8.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL41748 — IC50 = 0.2042 nM 9.69
CHEMBL186617 — IC50 = 0.3236 nM 9.49
CHEMBL187807 — IC50 = 0.3715 nM 9.43
CHEMBL186906 — IC50 = 0.3715 nM 9.43
CHEMBL187128 — IC50 = 0.3802 nM 9.42
CHEMBL184330 — IC50 = 0.4467 nM 9.35
CHEMBL181748 — IC50 = 0.5012 nM 9.30
CHEMBL183953 — IC50 = 0.5888 nM 9.23
CHEMBL182171 — IC50 = 0.6026 nM 9.22
CHEMBL186927 — IC50 = 0.631 nM 9.20
CHEMBL362881 — IC50 = 0.6607 nM 9.18
CHEMBL363041 — IC50 = 0.8128 nM 9.09
CHEMBL360525 — IC50 = 0.8128 nM 9.09
CHEMBL184916 — IC50 = 0.912 nM 9.04
CHEMBL184537 — IC50 = 0.9333 nM 9.03
CHEMBL359959 — IC50 = 1.202 nM 8.92
CHEMBL184568 — IC50 = 1.202 nM 8.92
CHEMBL1796675 — IC50 = 1.288 nM 8.89
CHEMBL183719 — IC50 = 1.318 nM 8.88
CHEMBL183832 — IC50 = 1.318 nM 8.88
CHEMBL179902 — IC50 = 1.318 nM 8.88
CHEMBL362519 — IC50 = 1.318 nM 8.88
CHEMBL365289 — IC50 = 1.318 nM 8.88
CHEMBL362750 — IC50 = 1.413 nM 8.85
CHEMBL183276 — IC50 = 1.514 nM 8.82
CHEMBL1796645 — IC50 = 1.514 nM 8.82
CHEMBL186715 — IC50 = 1.514 nM 8.82
CHEMBL361353 — IC50 = 1.738 nM 8.76
CHEMBL362338 — IC50 = 1.738 nM 8.76
CHEMBL183097 — IC50 = 1.738 nM 8.76
CHEMBL183356 — IC50 = 1.82 nM 8.74
CHEMBL1795359 — IC50 = 1.905 nM 8.72
CHEMBL182330 — IC50 = 1.905 nM 8.72
CHEMBL368904 — IC50 = 2.042 nM 8.69
CHEMBL182679 — IC50 = 2.138 nM 8.67
CHEMBL365427 — IC50 = 2.239 nM 8.65
CHEMBL1796674 — IC50 = 2.512 nM 8.60
CHEMBL183224 — IC50 = 2.63 nM 8.58
CHEMBL184425 — IC50 = 3.02 nM 8.52
CHEMBL185058 — IC50 = 3.02 nM 8.52
CHEMBL183902 — IC50 = 3.548 nM 8.45
CHEMBL183523 — IC50 = 3.631 nM 8.44
CHEMBL182978 — IC50 = 4.074 nM 8.39
CHEMBL361357 — IC50 = 4.169 nM 8.38
CHEMBL182810 — IC50 = 4.365 nM 8.36
CHEMBL188127 — IC50 = 4.365 nM 8.36
CHEMBL185416 — IC50 = 4.467 nM 8.35
CHEMBL1796664 — IC50 = 4.786 nM 8.32
CHEMBL187037 — IC50 = 4.786 nM 8.32
CHEMBL1796648 — IC50 = 5.248 nM 8.28