Compound Detail

CHEMBL183276

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Cn1cncc1C(OCc1ccc(C#N)cc1)c1ccc(C#N)c(-c2cccc(Cl)c2Cl)c1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL183276
Phase	Preclinical
Structure Type	MOL
InChI Key	WDRQPZYKUXVXMT-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

473.4

MW (Da)

6.44

ALogP

HBA

HBD

74.6

PSA (Å²)

0.32

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 3 meas. best 8.82

EC50 1 meas. best 6.62

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Protein farnesyltransferase CHEMBL2095178	IC50	8.82	8.82	1.5	1
Unchecked CHEMBL612545	IC50	8.82	8.82	1.5	1
Geranylgeranyl transferase type I CHEMBL2096987	IC50	7.07	7.07	85.0	1
Protein farnesyltransferase CHEMBL2096912	EC50	6.62	6.62	240.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Protein farnesyltransferase	IC50	=	1.5	nM	8.82	Inhibition of Bovine farnesyl transferase	15582430
Unchecked	IC50	=	1.514	nM	8.82	Inhibition of farnesyltransferase	17448576
Geranylgeranyl transferase type I	IC50	=	85.0	nM	7.07	Inhibition of Bovine geranylgeranyl transferase	15582430
Protein farnesyltransferase	EC50	=	240.0	nM	6.62	Effective concentration against H-ras processing in transformed NIH3T3 cells	15582430

PubMed	DOI	Target Context	# Activities
15582430	10.1016/j.bmcl.2004.10.014	Protein farnesyltransferase	2
15582430	10.1016/j.bmcl.2004.10.014	Geranylgeranyl transferase type I	1
17448576	10.1016/j.ejmech.2007.02.003	Unchecked	1

Data from ChEMBL 36 via Core Engine