Assay Detail
Binding
CHEMBL829564
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Inhibition of Bovine geranylgeranyl transferase
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.20 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41748 | — | — | 1 | 7.75 |
| CHEMBL183097 | — | — | 1 | 7.14 |
| CHEMBL183276 | — | — | 1 | 7.07 |
| CHEMBL361357 | — | — | 1 | 6.92 |
| CHEMBL182679 | — | — | 1 | 6.89 |
| CHEMBL182812 | — | — | 1 | 6.80 |
| CHEMBL182978 | — | — | 1 | 6.75 |
| CHEMBL360525 | — | — | 1 | 6.51 |
| CHEMBL183725 | — | — | 1 | 6.32 |
| CHEMBL183523 | — | — | 1 | 6.17 |
| CHEMBL182180 | — | — | 1 | 6.12 |
| CHEMBL368904 | — | — | 1 | 6.04 |
| CHEMBL183902 | — | — | 1 | 6.01 |
| CHEMBL179902 | — | — | 1 | 5.92 |
| CHEMBL183356 | — | — | 1 | 5.85 |
| CHEMBL183832 | — | — | 1 | 5.85 |
| CHEMBL181318 | — | — | 1 | 5.82 |
| CHEMBL361353 | — | — | 1 | 5.80 |
| CHEMBL183224 | — | — | 1 | 5.75 |
| CHEMBL183719 | — | — | 1 | 5.70 |
| CHEMBL360694 | — | — | 1 | 5.66 |
| CHEMBL359950 | — | — | 1 | 5.64 |
| CHEMBL183372 | — | — | 1 | 5.62 |
| CHEMBL359959 | — | — | 1 | 5.58 |
| CHEMBL179857 | — | — | 1 | 5.41 |
| CHEMBL368218 | — | — | 1 | - |
| CHEMBL183246 | — | — | 1 | - |
| CHEMBL183548 | — | — | 1 | - |
| CHEMBL182330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41748 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL183097 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL183276 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL361357 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL182679 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL182812 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL182978 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL360525 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL183725 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL183523 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL182180 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL368904 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL183902 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL179902 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL183356 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL183832 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL181318 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL361353 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL183224 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL183719 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL360694 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL359950 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL183372 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL359959 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL179857 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL368218 | — | IC50 | - | nM | - | |
| CHEMBL183246 | — | IC50 | - | nM | - | |
| CHEMBL183548 | — | IC50 | - | nM | - | |
| CHEMBL182330 | — | IC50 | - | nM | - |