Assay Detail
Functional
CHEMBL833108
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Effective concentration against H-ras processing in transformed NIH3T3 cells
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.03 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183356 | — | — | 1 | 7.96 |
| CHEMBL183832 | — | — | 1 | 7.89 |
| CHEMBL182180 | — | — | 2 | 7.80 |
| CHEMBL183719 | — | — | 1 | 7.52 |
| CHEMBL359959 | — | — | 1 | 7.28 |
| CHEMBL360525 | — | — | 1 | 7.07 |
| CHEMBL179902 | — | — | 1 | 7.05 |
| CHEMBL181318 | — | — | 1 | 7.05 |
| CHEMBL361357 | — | — | 1 | 7.00 |
| CHEMBL182330 | — | — | 1 | 6.96 |
| CHEMBL41748 | — | — | 1 | 6.96 |
| CHEMBL183902 | — | — | 1 | 6.92 |
| CHEMBL183224 | — | — | 1 | 6.89 |
| CHEMBL368904 | — | — | 1 | 6.77 |
| CHEMBL360694 | — | — | 1 | 6.70 |
| CHEMBL183523 | — | — | 1 | 6.68 |
| CHEMBL183276 | — | — | 1 | 6.62 |
| CHEMBL183372 | — | — | 1 | 6.54 |
| CHEMBL361353 | — | — | 1 | 6.48 |
| CHEMBL182978 | — | — | 1 | 6.38 |
| CHEMBL182812 | — | — | 1 | - |
| CHEMBL179857 | — | — | 1 | - |
| CHEMBL182679 | — | — | 1 | - |
| CHEMBL183246 | — | — | 1 | - |
| CHEMBL183548 | — | — | 1 | - |
| CHEMBL183725 | — | — | 1 | - |
| CHEMBL359950 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183356 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL183832 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL182180 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL183719 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL359959 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL360525 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL181318 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL179902 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL361357 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL182330 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL41748 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL183902 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL183224 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL368904 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL360694 | — | EC50 | = | 201.0 | nM | 6.70 |
| CHEMBL183523 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL183276 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL183372 | — | EC50 | = | 285.0 | nM | 6.54 |
| CHEMBL361353 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL182978 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL182812 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL182679 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL179857 | — | EC50 | = | 83.0 | % | - |
| CHEMBL183246 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL183548 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL183725 | — | EC50 | = | 89.0 | % | - |
| CHEMBL182180 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL359950 | — | EC50 | > | 1000.0 | nM | - |