Assay Detail
Binding
CHEMBL1798408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells by scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.57 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241987 | — | — | 1 | 7.51 |
| CHEMBL1795502 | — | — | 1 | 6.30 |
| CHEMBL320805 | — | — | 1 | 6.26 |
| CHEMBL1795500 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241987 | — | Ki | = | 30.8 | nM | 7.51 |
| CHEMBL1795502 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL320805 | — | Ki | = | 551.0 | nM | 6.26 |
| CHEMBL1795500 | — | Ki | = | 600.0 | nM | 6.22 |