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Compound Detail

CHEMBL241987

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O=c1[nH]c2ccccc2c2cn(-c3ccccc3)nc12

Basic Information

ChEMBL ID CHEMBL241987
Phase Preclinical
Structure Type MOL
InChI Key ISMLHIIGSRUCOQ-UHFFFAOYSA-N
4
Targets
7
Activities
2
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

261.3
MW (Da)
2.87
ALogP
3
HBA
1
HBD
50.7
PSA (Ų)
0.57
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H11N3O
MW 261.28
Aromatic Rings 4
Heavy Atoms 20
NP-Likeness -1.01

Activity Summary

Ki 6 meas. best 7.51
EC50 1 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 7.51 7.51 30.8 2
Adenosine receptor A1
CHEMBL226
Ki 6.69 6.69 203.0 2
Adenosine receptor A1
CHEMBL4975
Ki 5.68 5.68 2100.0 1
Adenosine receptor A2a
CHEMBL251
Ki 5.07 5.07 8600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10956220 10.1021/jm000936i Adenosine receptor A1 1
10956220 10.1021/jm000936i Adenosine receptor A2a 1
10956220 10.1021/jm000936i Adenosine receptor A3 1
17665891 10.1021/jm070123v Adenosine receptor A1 1
17665891 10.1021/jm070123v Adenosine receptor A2a 1
21616671 10.1016/j.bmc.2011.05.001 Adenosine receptor A3 1
21616671 10.1016/j.bmc.2011.05.001 Adenosine receptor A1 1
21616671 10.1016/j.bmc.2011.05.001 Adenosine receptor A2b 1
21616671 10.1016/j.bmc.2011.05.001 Adenosine receptor A2a 1

Data from ChEMBL 36 via Core Engine