Assay Detail
Binding
CHEMBL642431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of specific [3H]CHA binding at adenosine A1 receptor in bovine brain membranes
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.72 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106520 | — | — | 1 | 8.49 |
| CHEMBL104115 | — | — | 1 | 8.07 |
| CHEMBL317270 | — | — | 1 | 8.03 |
| CHEMBL442005 | — | — | 1 | 7.65 |
| CHEMBL104425 | — | — | 1 | 7.57 |
| CHEMBL107414 | — | — | 1 | 7.39 |
| CHEMBL104177 | — | — | 1 | 7.26 |
| CHEMBL106986 | — | — | 1 | 7.22 |
| CHEMBL320805 | — | — | 1 | 7.16 |
| CHEMBL106906 | — | — | 1 | 7.14 |
| CHEMBL320741 | — | — | 1 | 7.12 |
| CHEMBL322263 | — | — | 1 | 7.07 |
| CHEMBL320283 | — | — | 1 | 6.97 |
| CHEMBL321441 | — | — | 1 | 6.96 |
| CHEMBL107446 | — | — | 1 | 6.89 |
| CHEMBL107116 | — | — | 1 | 6.88 |
| CHEMBL419002 | — | — | 1 | 6.83 |
| CHEMBL107571 | — | — | 1 | 6.73 |
| CHEMBL106346 | — | — | 1 | 6.67 |
| CHEMBL105913 | — | — | 1 | 6.62 |
| CHEMBL104478 | — | — | 1 | 6.55 |
| CHEMBL106740 | — | — | 1 | 6.33 |
| CHEMBL318323 | — | — | 1 | 6.32 |
| CHEMBL107637 | — | — | 1 | 6.28 |
| CHEMBL322228 | — | — | 1 | 6.23 |
| CHEMBL387592 | — | — | 1 | 6.08 |
| CHEMBL320093 | — | — | 1 | 6.02 |
| CHEMBL242203 | — | — | 1 | 5.97 |
| CHEMBL106040 | — | — | 1 | 5.91 |
| CHEMBL108178 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106520 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL104115 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL317270 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL442005 | — | Ki | = | 22.2 | nM | 7.65 |
| CHEMBL104425 | — | Ki | = | 27.1 | nM | 7.57 |
| CHEMBL107414 | — | Ki | = | 40.7 | nM | 7.39 |
| CHEMBL104177 | — | Ki | = | 54.7 | nM | 7.26 |
| CHEMBL106986 | — | Ki | = | 60.1 | nM | 7.22 |
| CHEMBL320805 | — | Ki | = | 69.2 | nM | 7.16 |
| CHEMBL106906 | — | Ki | = | 71.9 | nM | 7.14 |
| CHEMBL320741 | — | Ki | = | 75.9 | nM | 7.12 |
| CHEMBL322263 | — | Ki | = | 86.1 | nM | 7.07 |
| CHEMBL320283 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL321441 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL107446 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL107116 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL419002 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL107571 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL106346 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL105913 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL104478 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL106740 | — | Ki | = | 464.0 | nM | 6.33 |
| CHEMBL318323 | — | Ki | = | 478.0 | nM | 6.32 |
| CHEMBL107637 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL322228 | — | Ki | = | 583.0 | nM | 6.23 |
| CHEMBL387592 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL320093 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL242203 | — | Ki | = | 1078.0 | nM | 5.97 |
| CHEMBL106040 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL108178 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL241987 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL104178 | — | Ki | = | 2290.0 | nM | 5.64 |
| CHEMBL324419 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL242202 | — | Ki | = | 3900.0 | nM | 5.41 |