Assay Detail
Binding
CHEMBL1798404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cell membranes by scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.51 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795497 | — | — | 1 | 7.00 |
| CHEMBL1795495 | — | — | 1 | 6.85 |
| CHEMBL241987 | — | — | 1 | 6.69 |
| CHEMBL1795496 | — | — | 1 | 6.52 |
| CHEMBL1795499 | — | — | 1 | 6.34 |
| CHEMBL320805 | — | — | 1 | 6.18 |
| CHEMBL1795502 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795497 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1795495 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL241987 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL1795496 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL1795499 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL320805 | — | Ki | = | 659.0 | nM | 6.18 |
| CHEMBL1795502 | — | Ki | = | 970.0 | nM | 6.01 |